Location: Leavenworth County, Kansas
Notable Residents: Jimmy Burke, Whitey Bulger, George "Machine Gun" Kelly, George "Bugs" Moran, Antonio Fernandez, Michael Vick, Byron "Bam" Morris, James Earl Ray, Robert Stroud
Amenities: A Panopticon-style design that allows guards to see prisoners without being seen

Operated by the Federal Bureau of Prisons and located 25 miles north of Kansas City, USP Leavenworth is a medium-security prison for men that also includes a minimum-security satellite camp for male prisoners. It is the oldest of the three major prisons built on Fort Leavenworth, and was the largest maximum-security prison in the USA for over a century, until it was downgraded to a medium-security prison in 2005. It is one of the original federal prisons. Prior to its existence, federal prisoners were held at state prisons.

USP Leavenworth boasts a design made popular by Auburn Correctional Facility, where cell blocks are located in a large, rectangular construction. It's domed main building is known as the "Big Top" or "Big House," while the Disciplinary Barracks are known as "Little Top." Between 1901 and 1974, five officers and two non-officers have been killed at USP Leavenworth.