Bill Murray is, low-key, one of the greatest living actors. Best known for comedy goldmines like Ghostbusters and Groundhog Day, Murray goes deeper than that. He has a chameleon-like adaptability for roles both funny and serious.
Murray was a part of everyone's childhood with the beloved Space Jam, but he can just as effectively play an aging movie star going through a mid-life crisis and still come off as compelling (see: Lost in Translation). Murray received a Best Actor nomination for that performance, but ultimately lost. His day will (hopefully) come, but until then we'll keep considering him an underdog.