As seen on: The Nanny (CBS)
Portrayed by: Fran Drescher

You know the laugh, and you probably haven't watched a single episode. That's how pervasive Ms. Drescher's glass-shattering laugh is in television history.

The Nanny was her platform. If the children said something she found adorable or ridiculous, that laugh happened. After she delivered a line, that laugh, yes, happened. Leaving The Nanny on in the background leaves you vulnerable to Fran's laugh sending shivers up your spine when you least expect it.