Pokemon's First Appearance: Pokemon Gold, Silver & Crystal

Don't let Misdreavus' small appearance fool you: it could probably take out a Machamp. How? Well, Misdreavus is immune to Fighting-type Pokemon and attacks, and it uses a handful of Psychic-based attacks. (Which is one of Machamp's weaknesses.) However, Misdreavus doesn't have that great of a selection with non-damaging and damaging moves, and its base stat total is really low (435). It's also weak against Ghost and Dark-type Pokemon and attacks. Yes, we're wondering the same thing you are: how is Misdreavus weak against Ghost-type Pokemon and attacks when it's a Ghost Pokemon? The world may never know.