4. Alyssa from "I Have Tourette's Syndrome"
Air date: October 10, 2006
Watch a clip here
Some True Life episodes are straight jokes. Not this one. Alyssa, a young girl with Tourette's Syndrome, is preparing to have "deep brain stimulation" surgery to cure her impulses. Watching the grim realities of Alyssa's day-to-day life coping with her disability is heartbreaking (especially when you imagine what her grandmother is going through). In the most famous moment of the episode, she snaps about her hair and screams on her grandmother while they prepare to leave for Disneyland. It's the best Six Flags advertisement ever made.
Since the episode's airing, and her brain surgery, Alyssa has become better at controlling her outbursts.