Year: 2010
System: Wii

Possibly one of the more obscure titles to make this list, Fluidity has you controlling a body of water in a metroidvania-style world in various states. Interestingly, most of the control over the water is done by tilting the screen to the left or right, sending your puddle splashing over the scenery (with highly impressive physics to boot). As if using water to operate rotational power devices and the like wasn’t cool enough, later in the game you can transform into a cloud or even freeze in a block of ice. Finally, a good scientific reason to use Wiiware.