Portrayed by: T.R. Knight
Dies in: "Now or Never" (Season 5, Episode 24)

It’s the execution, no pun intended, of George’s death that really hits home. The staff at Seattle Grace are steeling themselves for his departure to become a field surgeon in the military, while organizing a combined effort to convince him to stay.

They’re also working on a horribly disfigured John Doe, rushed in from a bus accident, while waiting for George to return. And then series creator Shonda Rhimes effortlessly pulls the rug out, when John Doe manages to communicate his identity thanks to a bittersweet call back to the early internship days: John Doe is George. By the time Meredith and the gang realize it, it’s already too late to say their goodbyes.