Reese Witherspoon as Sidney Prescott (Scream, 1996)
To those that have actually seen it, Wes Craven’s Scream is clearly a satirical, self-aware look at the horror genre, but thinking its just another B-horror movie is an easy mistake to make based off the name and promotional material. It was this that prompted Reese Witherspoon to turn down the lead role of Sidney Prescott when it was offered to her—she thought it was just another horror movie. The role eventually went to Neve Campbell, and the franchise went on to spawn three sequels. Witherspoon did alright regardless, though—apart from a fairly embarrassing arrest in Atlanta, she won an Oscar for her role in 2005’s Walk the Line.