Game: Crysis (2007)

While the Nanosuit has made you a badass against enemy soldiers, armored vehicles and even Ceraph alien shock troops, your precious exoskeleton doesn't mean squat against this boss. Rising from the ocean, the alien warship has turrets, shields and the ability to release attack drones on command. Your weapons barely scratch its hull and you have to rely on timing, assistance from a nearby chopper and your trusty TAC gun.