First appearance: “Who Shot Mr. Burns? (Part 2)” (Season 7, Episode 1)
Voiced by: Hank Azaria
Dr. Colossus only has one conversation throughout the 24 years that The Simpsons has been on the air, but it’s so absurd and hilarious that there's no way he you could make this list without including him. In “Who Shot Mr. Burns? (Part 2),” Colossus appears briefly in a prison cell at the Springfield Police Station, where he mocks Mr. Burns’ plan to block out the sun. With the operatic boasting of a comic book villain, he screams from his cell, “Bah! He is a rank amateur compared to Dr. Colossus!”
He then hits the secret button on his extending “Colosso-Boots,” which causes him to slam his head on the ceiling of his prison cell. It’s a short and brilliant scene, but it instantly makes us wish for a spin-off featuring Colossus fumbling around his devious hideout at Death Mountain.