First appearance: “The Crepes of Wrath” (Season 1, Episode 11)
Notable appearance: “The Twisted World of Marge Simpson” (Season 8, Episode 11)
Voiced by: Tress MacNeille

In nearly every episode Agnes Skinner appears in, she delivers the quote of the night. And yet viewers fail to recognize her brilliance. She’s a crass and overbearing mother, whose mission in life is to emasculate her son, Principal Skinner, whenever she gets the chance. His unsettling, Norman Bates-esque relationship with her is still one of the best things on the show.

Whether she's berating Seymour for his dead-end job, mocking him for not having a computer full of pornography, or arguing with him over the use of their infamous bath pillow, Agnes is a tactless old bat with absolutely no redeeming qualities. And that's why we love her.