Eminem in Funny People (2009)
Director: Judd Apatow
The movie about funnyman George Simmons (Adam Sandler) takes a depressing turn when he finds out he has a terminal disease. In need of some life advice, Simmons turns to his unlikely BFF, Eminem, who tells him he should just go die, before cursing out Ray Romano in a fit of rage for wanting to take a photo of him. That's a good cameo.