21. Wile E. Coyote, LooneyTunes
Voice By: Mel Blanc
Rube-Goldberg-machine-loving carnivore Wile E. Coyote has captured the popular imagination in ways the most villains could never hope to—do you see people walking around with J.R. Ewing tattoos or Gus Fring pajamas? Not often.
What began as a parody of popular chase cartoons (specifically Tom & Jerry) morphed into the most popular animated chase sagas of all time. In the 65 years since the invention of the sinister coyote and his elusive would-be quarry, over 40 animated shorts have been produced documenting their epic struggle. The ending is always the same: Wile E. Coyote suffers immense physical pain. Being the villain is not always a good gig.