Amy, the wife of Raymond's brother on the show, has a weird family, we can all agree with that. Originally, her brother was introduced as Russell, and played by Pee-Wee Herman himself, Paul Reubens. But then, unexpectedly, a new brother named Peter, played by Chris Elliott, took his spot. It wasn't explained where Russell went; we were just supposed to accept that it has been Peter all along.
So why was Reubens so easily cast aside? Shortly after his episode aired as the loving brother, he was arrested on child pornography charges and Ray Romano didn't want that associated with his family friendly show. Yeah, good call.