23. Season 1 vs. Season 2
In 2012, series creator David Chase told Vanity Fair that "The Sopranos was ambiguous to the point where, to this day, I'm not really sure whether it was a drama or a comedy."
While fans of the show might immediately lean toward drama when picking a genre (and a nihilstic one at that), Chase is correct in that the show was able to successfully meld these tones in new and innovative ways.
But, from a tonal perspective, his genre confusion seems most pronounced when you analyze the differences from season one to season two. Sure, any "new show" will spend the first season finding its legs; but the change from comedy to drama as the prevalent feeling is palpable when you watch those two seasons back to back.