Network: ABC
Air Dates: September 22, 2004 – May 23, 2010
Stars: Matthew Fox, Evangeline Lilly, Terry O'Quinn, Jorge Garcia, Josh Holloway, Daniel Dae Kim, Yunjin Kim, Harold Perrineau, Ian Somerhalder, Dominic Monaghan, Maggie Grace, Naveen Andrews, Henry Ian Cusick, Emilie de Ravin, Elizabeth Mitchell, Michael Emerson, Jeff Fahey

Three years removed from its divisive finale, we're still pondering the after-effects of ABC's Lost, trying to decide whether its long-awaited conclusion was satisfactory or chump style. Either way, the singular hit—about survivors of an airplane crash stranded on a mysterious island where flashbacks, flash-forwards, and even flash-sideways are the norm—is a once-in-a-lifetime kind of program, one that, even in its most confusing and frustrating hours, took creative risks that subsequent shows have failed miserably trying to emulate. —MB