Most Recent Projects: The Office (2008-2011), Win Win (2011), In Treatment (2010)

The Prognosis
: From a critic's standpoint, Amy Ryan is one of the most successful people to come out of The Wire, if not the most successful. She's acted on one of the most popular and, for a time, acclaimed comedies on network TV, The Office; she's done the indie movie thing with guys like Paul Giamatti (Win Win) and Philip Seymour Hoffman (Jack Goes Boating); and she continued to work with HBO on In Treatment, a master's class in acting.