25. Taraji P. Henson
Most Memorable Roles: Shug in Hustle and Flow (2005)
In The Curious Case of Benjamin Button, Henson raises Brad Pitt, who ages backwards. This role came after scene stealing turns in John Singleton's Baby Boy and Hustle and Flow. Like Benjamin Button, this D.C. native's career seems to get better with time. She's now a regular in the hit CBS drama, Person of Interest.