11. Sarah Silverman
Sarah Silverman isn't scared. Her stand-up routines and her Comedy Central series, The Sarah Silverman Program, routinely confronts racism, abortion, and religion without pause; she named her 2005 documentary Jesus is Magic, and has even done a bit about how 9/11 was the worst day of her life—because it was the day that she found out a soy chai latte had 900 calories.
Silverman has cleverly embraced stereotypes about the cuteness and meekness of women to deliver the most caustic jokes, and it's brilliant.
Her most recent controversy: Fake photos of her before and after an abortion, which she put up on Twitter in response to Mitt Romney’s intentions to overturn Roe v. Wade.