Best Known For: When Harry Met Sally (1989), Sleepless in Seattle (1993)
Most Recent Project: Serious Moonlight (2009)

When Harry Met Sally and its famous Katz's Deli orgasm announced Meg Ryan as America's sweetheart, catapulting her to superstardom. Though she sought roles that would challenge America's perception of her as a rom-com mainstay, her boy-meets-girl genre pictures dominated the decade. A series of critical missteps, including a brief dalliance with Russell Crowe and whatever you want to call In the Cut culminated in her taking a three-year hiatus from acting. Her return to the silver screen has been marked by a low profile, as she's focused on passion projects and indie films.