Most Notable Movie: Big (1988)

Marshall was best known as the cynical Laverne of Laverne & Shirley, but through the encouragements of her brother, famed rom-com director Garry Marshall, she started to grow interested in directing. After directing two episodes of her hit show, she realized she was destined for more.

In 1988, her now-classic comedy, Big, starring Tom Hanks as a 30-year-old 12-year-old, was released, and became the first film directed by a woman to gross over $100 million in the U.S. box office. Two years later, her film Awakening earned her a nomination in the Academy Award for Best Picture.