As Seen In: Live and Let Die (1973)
Villains in James Bond movies are rarely killed in casual ways. If we had to pick one, though, in regards to the most unenviable way to go out, it'd be the manner in which Live and Let Die bad guy Dr. Kananga (Yaphet Kotto) breathes his last bit of air.
Before Kananga is able to lower him into a shark tank, Bond (Roger Moore) escapes, tangles with the doctor, and slips a shark gun pellet into his foe's mouth. Somehow (nobody ever pinned 007 movies as beacons of scientific truth) the pellet makes Kananga blow up like a blimp, sending him floating out of the lair and into the sky, where he explodes.