Stars: Edie Falco, Eve Best, Peter Facinelli, Merritt Wever, Paul Schulze, Dominic Fumusa, Anna Deavere Smith, Stephen Wallem, Bobby Cannavale, Ruby Jerins

Nurse Jackie might be the most unfairly misconceived show on television, mainly amongst the dude sect. Ask nine guys on the street if they've ever watched the dark Showtime comedy and you're likely to be met with blank stares and fuck-outta-here indifference. What's to blame? Perhaps a certain close-mindedness about a show centered on a middle-aged woman (the always stellar Edie Falco) and her mixture of workplace drama and domestic headaches.

Well, fellas in question, you're missing out on one of TV's best written, intriguingly complicated, and scathingly funny characters. As the titular pill-popper, Falco leads an eclectic cast of comedic talents, an ensemble that grew in strength during the half-hour show's fourth season, its greatest one yet. Bolstered by the addition of the underrated Bobby Cannavale as NYC's All Saints' Hospital tyrannical new leader, Nurse Jackie's wicked support team all brilliantly conveyed the hospital's eroding sense of order.

Yet it's always Falco who pushes Nurse Jackie into that upper echelon of cable television superiority. With Jackie's life in a tailspin, due to an erratic stint in drug rehab and a bitter divorce, the four-time Emmy-winning actress showed viewers why she's a foolproof lock for a nomination year in and year out. Per usual, she has our vote.