20. Louie (FX)
Star: Louis C.K.
More so than either of its previous two seasons, the one-of-a-kind FX comedy Louie's third year was marked by its exceptional guest stars. Series creator/star Louis C.K. is, of course, perfectly capable of bringing the wry hilarity all by himself, but the show's best moments in 2012 revolved around his combustibly hilarious interactions with Parker Posey and Melissa Leo, the latter killing it as a forceful blind dater with a dirty mouth and a knack for physical abuse.
Guests aside, Louie's dynamite third season ended with a dreamlike finale that cemented the show's reputable standing as TV's most progressive and unclassifiable sitcom.