Appeared In: Dr. No (1962)
Played By: Joseph Wiseman
Diabolical Weapon: Bionic metal hands
Killed By: Boiling to death in a nuclear reactor

The first major Bond villain to hit the screen, Dr. Julius No became the template for all of 007’s adversaries that followed. He is a man of incredible drive and has his sights set on world domination, but he’s also incredibly egotistical, which ultimately gets in the way of his own plans. He is an expert of radiation, but after an accident earlier in his life, he is left with bionic metal hands that greatly increase his strength but compromise his dexterity.

His plan to disrupt the launch of an American rocket into space through the use of an atomic-powered radio beam is ultimately foiled by Bond and he gets boiled in his own reactor. Death aside, No created the archetype for diabolic villains that we see today; in Bond flicks as well as in other movies, TV shows, video games, and even comic books.