21. The Mob Doctor (Fox)
Stars: Jordana Spiro, William Forsythe, Jaime Lee Kirchner, James Carpinello, Jesse Lee Soffer, Zach Gilford
Premiere date: September 17
Usually, the proposition of yet another medical TV series inspires instantaneous indifference, but there's more to Fox's The Mob Doctor than your basic Grey's Anatomy knockoff. Though it's set mostly inside a hospital, and stars an attractive female lead (Jordana Spiro, from the quietly popular TBS show My Boys), The Mob Doctor's protagonist has a clever, Sopranos-esque back-story: She's saving lives in order to keep her family members breathing as mobsters look to collect debts. Early positive word on the pilot episode only increases the show's chances of reinvigorating the ER trend.