Another self-explanatory title: Basically, contestants on this show were newlyweds, each episode had four couples competing against once another. Each contestant was asked questions about their spouse with their spouse sitting right next to them, and each correctly answered question earned the respective participant points. In the end, whichever couple with the most points won some prize that was sufficient for the '60s, like home appliances or furniture.
More often than not, though, The Newlywed Game just provided an insight into how little recently married folks really knew about their spouses, which was visible to both the audience and the newlyweds themselves. As if the divorce rate wasn't high enough already.