Comparisons to Fox's House (another prescription drug-addled, yet competent medical professional worthy of honorable mention) are just about inevitable, but the blessing of a home on premium cable allows the story of emergency room nurse Jackie Peyton's (Edie Falco) addiction to venture into much grittier territory.

How often do you see a med pro doing shots of morphine like J├Ąger? Or reaching levels of desperation so low they'd pocket Fentanyl patches meant for cancer patients? If you didn't suffer a fear of hospitals prior to Nurse Jackie, you may suddenly find yourself far more wary of your prospective caretakers. Even mob wife Carmela Soprano begins to look sane next to Peyton.