If you've played Heavy Rain, you're going to laugh at stand-up comedian Kumail Nanjiani's commentary of the game. Heavy Rain definitely ranks among the most depressing games ever, which is exactly Nanjiani thinks it's so funny.
I don't think there's been enough a stand-up comedy about video games. Maybe all the funny gamers are too busy trying to get their memes to stick, but it's not every day that you see professionals joke about games the way they do TV and movies. Nanjiani's bit is a sign of the permanence of gaming culture, and as much a validation of the game as it is critical.