Speaking of pipes, Gynecologist Mario would be dealing with a type he's not exactly used to. He's already a doctor, but considering what little play the guy gets, it's probably safe to say he's rather unfamiliar with the female anatomy—at least in a practical sense. There's only so much you can learn from a textbook.
A little hands-on experience might do the guy some good, even if it is from the other side of a stethoscope and a pair of stirrups. It would make for some interesting gameplay, as well. Think Trauma Center, but with more mental scarring. It's not like we'd ever see it outside of Japan, anyway, though Nintendo would make a fortune in their home country from the manga spinoffs alone.