One of the most glaring signs that an actor operates on the lower end of the spectrum is Hollywood's inability to sell him as a leading man. You could call it the "Luke Wilson effect"; agreeable whenever he's flanked by dominant personalities (Old School, Anchorman: The Legend Of Ron Burgundy), Owen's younger brother disappears whenever he's entrusted with top billing. Remember his front-and-center work in that cinematic gem Henry Poole Is Here? How about his rousing turn in the game-changing My Super Ex-Girlfriend? Of course you don't, because Luke-led movies have zero appeal.
38. Luke Wilson
Worst Performances: Blue Streak (1999), My Super Ex-Girlfiend (2006), Henry Poole Is Here (2008), Death At A Funeral (2010)