Worst Performances: Ready To Rumble (2000), 3000 Miles To Graceland (2000), See Spot Run (2001), Eight Legged Freaks (2002)

No matter the genre (comedy, horror, kid's fare), Arquette has one demeanor: Renfield after Dracula turned him into an asylum resident. Googly-eyed and ready to spazz out at any minute, Courtney Cox's ex-hubby always looks nervous, as if every scene he shoots is part of an audition. Makes you want to say, "Relax, dude—you got the part!" Well, somehow he did.