No matter the genre (comedy, horror, kid's fare), Arquette has one demeanor: Renfield after Dracula turned him into an asylum resident. Googly-eyed and ready to spazz out at any minute, Courtney Cox's ex-hubby always looks nervous, as if every scene he shoots is part of an audition. Makes you want to say, "Relax, dude—you got the part!" Well, somehow he did.
8. David Arquette
Worst Performances: Ready To Rumble (2000), 3000 Miles To Graceland (2000), See Spot Run (2001), Eight Legged Freaks (2002)