Insanity from Mass Effect 2
Description: Complete the game on the "Insanity" difficulty level without changing the setting.
Stallion Says: "Not impossible, but can be tricky. Some parts will take a lot of patience and skill. The hardest achievement in what I consider the game of 2010."
How to Get It: Beating any game on its hardest level is tough, but Mass Effect 2 happens to fall well in the Unforgiving category, taking a page out of its RPG lineage. The No. 1 thing to do here is try to survive long enough to recruit Mordin, Commander Shepard's personal professor of sorts. You can find him in the quarantined slums of Omega. Once recruited, he can upgrade your team's weaponry and armor—a must to help save the universe.