65. House (FOX)
Asshole genius Gregory House leads a team of doctors at a teaching hospital in New Jersey. He's arrogant, he's usually right, he's a pill-popper, and he gets some Cuddy every now and then (zing!). Sounds like someone we can fux with.
YOU AUGHTA KNOW:
The show makes several allusions to Sherlock Holmes. Some of them include: Dr. House's relationship to Dr. John Wilson (mirroring that of Holmes to Dr. Watson) and House's apartment number being 221B, just like Holmes' street address.