74. Futurama (FOX/Adult Swim)
Matt Groening's other show, about an intergalactic parcel delivery service, may have been set in 1,000 years in the future, but it was one big skewering of the way we live now. The characters weren't as memorable or quotable as their Simpsons counterparts (save for Bender), but at least this one didn't run past its sell-by date.
YOU AUGHTA KNOW:
The show may have a chance to wear out its welcome after all, as Comedy Central (the station that syndicated it after its cancellation) has ordered 26 new episodes set to air in 2010. Please, Mr. Groening, don't fuck this up.