Target: Entire Murder Inc. Roster, Ja Rule
Producer: Dr. Dre
Album: Get Rich or Die Tryin'
Label: Shady/Aftermath/Interscope
Best Line: "I'm back in the game, shorty, to rule and conquer/You sing for hoes and sound like the Cookie Monster"

By the time 50 Cent's debut album, Get Rich or Die Tryin', hit stores in early 2003, most hip-hop fans had already turned their backs on the once insanely popular Ja Rule and switched sides to align with the new kid on the block: Curtis Jackson.

Although 50 had been on a Ja Rule slander campaign for years (as far back as "Life's on the Line" in 2000), including hilarious skits and mixtape diss tracks, it wasn't until "Back Down" when 50 landed the true knockout blow. 50's attacks left Ja's career in shambles and created a new verb for hip-hop beef: being "Ja Rule'd."