10. Justin Timberlake "SexyBack" (2006)
EDM sounds are so prevalent in modern pop and R&B that it's easy to underestimate how much of a suckerpunch Justin Timberlake's "SexyBack" was when it dropped in 2006. The lead single from Timberlake's second album FutureSex/LoveSounds was a hard left into electronic music, ringing in on distorted synth blurts and a propulsive dance beat as Timbaland goofily brought in the bridge and chorus like a bandleader shouting directions to his support players. Looking back, "SexyBack" kicked off modern R&B's flirtation with electronic dance music values, and it's hard to say whether the Rihannas and Ushers would've dabbled with any of it if Justin didn't dive in headlong and come out with the biggest single of his career as a solo artist.