Album: The Drought Is Over 2
Producer: Rebel Rock Productions

Karma's "Once" is a poignant enough track, with the lead singer musing about her own demise once she's out of smack. But add Lil Wayne into the mix and the song turns even more twisted. Trading powder for syrup is interchangeable at that point, and given Wayne's substance abuse, the sample is very telling. It made for one of the most powerful and celebrated songs in Weezy's catalog.

Sample: Karma "Once" (2008)