Origin: 50 Cent's guest appearance on an episode of Entourage
50's "Laugh Off" is the perfect response to any and everything. Someone says something funny, you can respond with this. Someone says something corny, you can still respond with this. Someone responds with this? You can respond with the backwards version. And then they can respond with the Kermit/Bert version. Next thing you know, you're in an infinite loop of hilarityâ€”which is exactly what GIFs are supposed to be.