21. New Belgium Brewing Co.
Location: Fort Collins, Colorado
Year Established: 1991
The third largest brewery in the country, New Belgium's Fat Tire is one of the most popular brews where it's available-and one of the most lusted after where it's not. Now that the brewers are opening a second location in North Carolina, the east coast will likely have their own Fat Tire very soon. On top of that, their Lips of Faith series, small batch brews and often collaborations with fellow breweries like Dieu du Ciel in Canada, are probably the most innovative beers in their portfolio.