6. Harpoon Brewery
Location: Boston, Massachusetts
Year Established: 1986
By volume, Harpoon is the ninth largest brewery with two locations in Boston and in Windsor, Vermont. Most beer drinkers know them for their IPA and for their UFO Hefeweizen. But there's so much more to their portfolio then just a few fan favorites. They've been innovating with their barrel series brews, the Harpoon Dark in 22 ounce bottles, and several impressive seasonals released (and often reinvented) each year.