Don't try to pick her up. Have a conversation.
Treat her like a human being, because (HINT) she is one. Also, let's face it, the idea of picking a woman up is a superficial technique that uses attraction as an entry point. So, if you're less than attractive, that's definitely not the way to go.
Instead, charm her. Woo her with your wit. Get to know who she is and what she's passionate about. Focus on your conversation skills and leave the gimmicks at the door. Your aim is to convince her you're interested in her beyond her looks and, conversely, that you are worth getting to know yourself.